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CasNo： 145-13-1
MF： C21H32O2
Appearance： white to off-white powder
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Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
cholesterol
Progesterone
Pregnenolone
20α-hydroxyprogesterone
(20R)-20-Hydroxy-5-pregnen-3-on
11β-hydroxy-20α-dihydroprogesterone
| Conditions | Yield |
|---|---|
|
With
Ham's F-10 medium; mouse adrenal Y-1 cells;
at 37 ℃;
for 60h;
Product distribution;
metabolism, 14C-labeled, further stimulation by ACTH;
|
|
|
With
calf serum horse serum; Ham's F-10 medium; MEN medium; mouse adrenal Y-1 cells transformed by simian adenovirus SA-7;
at 37 ℃;
for 60h;
Product distribution;
|
Progesterone
16-dehydroprogesterone
17-methyltestosterone
Pregnenolone
21-Hydroxyprogesterone
pregna-4,7-diene-3,20-dione
pregnane-3,6,20-trione
pregnane-3,20-dione
| Conditions | Yield |
|---|---|
|
With
Hortaea werneckii B-763 at all growth phases;
In
YNB growth medium; N,N-dimethyl-formamide;
at 28 ℃;
for 24h;
Enzymatic reaction;
|
The CAS number of Pregnenolone is 145-13-1.
More information of Pregnenolone 145-13-1 are:
|
CAS Number |
145-13-1 |
|
Density |
1.09 g/cm3 |
|
Melting Point |
188-190 °C |
|
Boiling Point |
443.3 °C at 760 mmHg |
|
Flash Point |
188.9 °C |
|
Vapor Pressure |
1.02E-09mmHg at 25°C |
|
Refractive Index |
1.5344 (estimate) |
|
HS CODE |
29372900 |
|
PSA |
37.30000 |
|
LogP |
4.51530 |
|
Pka |
15.00±0.70(Predicted) |
Synonyms for Pregnenolone 145-13-1:3-beta-Hydroxypregn-5-en-20-one;3beta-Hydroxy-Delta5-pregnen-20-one;3beta-Hydroxy-5-pregnene-20-one;Delta5-Pregnen-3beta-ol-20-one;Pregn-5-ene-3beta-ol-20-one;Pregnenolone:Pregna-5-ene-3beta-ol-20-one;Arthenolone;
The chemical formula of Pregnenolone is C21H32O2 which containing 21 Carbon atoms,32 Hydrogen atoms and 2 Oxygen atoms,and the molecular weight of Pregnenolone is 316.484.
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens. Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).
InChI:InChI=1/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18?,19?,20-,21+/m0/s1
Relevant articles related to Pregnenolone:
|
Article |
Source |
|
Enzymatic deacetylation of steroids bearing labile functions |
Baldessari, Alicia,Maier, Marta S.,Gros, Eduardo G. , p. 4349 - 4352 (1995) |
|
Ile351, Leu355 and Ile461 residues are essential for catalytic activity of bovine cytochrome P450scc (CYP11A1) |
Glyakina, Anna V.,Strizhov, Nicolai I.,Karpov, Mikhail V.,Dovidchenko, Nikita V.,Matkarimov, Bakhyt T.,Isaeva, Ludmila V.,Efimova, Vera S.,Rubtsov, Mikhail A.,Novikova, Ludmila A.,Donova, Marina V.,Galzitskaya, Oxana V. , p. 80 - 90 (2019) |
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