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CasNo： 50-24-8
MF： C21H28O5
Appearance： Crystalline Solid
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Prednisolone is used for the same indications as all corticosteroids: rheumatism, polyarthritis, bronchial asthma, neurodermatitis, and eczema.
prednisolone 21-acetate
prednisolon
| Conditions | Yield |
|---|---|
|
With
water; potassium carbonate; sodium hydroxide;
In
methanol;
at 0 - 10 ℃;
for 2h;
Inert atmosphere;
|
92.5% |
|
With
methanol; triethylamine;
for 14h;
Ambient temperature;
|
49% |
|
With
potassium hydroxide;
|
|
|
prednisolone 21-acetate;
With
water; sodium hydroxide;
In
methanol; dichloromethane;
at 0 - 30 ℃;
for 2.5h;
Inert atmosphere;
With
acetic acid;
In
methanol; dichloromethane;
at -12 - -5 ℃;
for 1h;
pH=6 - 7;
Reagent/catalyst;
Reflux;
|
15.8 g |
HYDROCORTISONE
prednisolon
| Conditions | Yield |
|---|---|
|
With
Rhodococcus coprophilus DSM 43347;
In
dimethyl sulfoxide;
at 30 ℃;
for 24h;
Reagent/catalyst;
regiospecific reaction;
Green chemistry;
|
97% |
|
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
1,4-dioxane;
for 4h;
Reflux;
|
83.33% |
|
With
potassium phosphate buffer;
In
methanol;
at 30 ℃;
free and the urethane prepolymer-entrapped acetone-dried cells of Arthrobacter simplex; effect of gel hydrophobicity; effect of electron acceptors and solvents;
|
|
|
With
3-ketosteroid-Δ1-dehydrogenase from Mycobacterium smegmatis mc2155; phenazine methosulfate;
In
dimethyl sulfoxide;
at 30 ℃;
for 16h;
pH=8;
Solvent;
Reagent/catalyst;
Catalytic behavior;
Kinetics;
Enzymatic reaction;
|
The CAS number of Prednisolone is 50-24-8.
More information of Prednisolone 50-24-8 are:
|
CAS Number |
50-24-8 |
|
Density |
1.31 g/cm3 |
|
Melting Point |
240 °C (dec.)(lit.) |
|
Boiling Point |
570.6 °C at 760 mmHg |
|
Flash Point |
313 °C |
|
Vapor Pressure |
7.36E-16mmHg at 25°C |
|
Refractive Index |
100 ° (C=1, Dioxane) |
|
HS CODE |
2937229000 |
|
PSA |
94.83000 |
|
LogP |
1.55760 |
|
Pka |
12.46±0.70(Predicted) |
Synonyms for Prednisolone 50-24-8:Predonin;Supercortisol;Codelcortone;Prestwick_404;Precortancyl;Cortalone;Dydeltrone;Fernisolone;Meti-Derm;Donisolone;K 1557;Paracortol;Cotogesic;Paracotol;Precortilon;Sterolone;Delcortol;Rolisone;Precortalon;Hydrodeltalone;Delta-Ef-Cortelan;Delta-cortef (TN);component of Ataraxoid;Prenolone;Cordrol;Hydeltra;(8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;Meticortelone;Deltacortenol;Sterane;Delta F;Precortisyl;Ulacort;Meticortelone;Sterolone;Deltisilone;Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-;Decortin H;1-Dehydrohydrocortisone;Prednis;Pregna-1,4-diene-3,20-dione,11,17,21- trihydroxy-,(11a)-;Predonine;Lentosone;1, 2-Dehydrohydrocortisone;Hydroretrocortin;Deltacortril;Di-Adreson F;Derpo PD;Deltahydrocortisone;Dexa-Cortidelt Hostacortin H;Hostacortin H;Scherisolon;Hydrodeltisone;Metacortandralone;Ultracortene-H;Ultracorten H;Fernisolone P;
The chemical formula of Prednisolone is C21H28O5 which containing 21 Carbon atoms,28 Hydrogen atoms and 5 Oxygen atoms,and the molecular weight of Prednisolone is 360.45.
Prednisolone is the active metabolite of the synthetic corticosteroid prednisone , which is used in the suppression of inflammation and autoimmunity, as well as in other conditions. It alters gene expression through both the glucocorticoid and mineralocorticoid receptors.
InChI:InChI=1/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-18,20,26,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
Relevant articles related to Prednisolone:
|
Article |
Source |
|
Microbial transformation of topical corticosteroid: Prednicarbate |
Ahmad, Saeed,Mukhtar, Muhammad Fahad,Khaliq, Farhan Hameed,Irshad, Sajid,Iqbal, Javed , p. 6043 - 6046 (2014) |
|
Preparation method of prednisolone acetate |
- Paragraph 0147; 0170-0174, (2021/02/20) |
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