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CasNo: 625-08-1
MF: C5H10O3
Appearance: colorless to light yellow liquid
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3-Hydroxy-3-methylbutyric acid is a useful biochemical for synthesis and proteomics research. It is used as an indicator of biotin deficiency. Further, it is used to increase muscle mass and decrease muscle breakdown. In addition to this, it is involved in the protein synthesis.
4-Hydroxy-4-methyl-2-pentanone
chloroform
3-Hydroxy-3-methylbutyric acid
Conditions | Yield |
---|---|
4-Hydroxy-4-methyl-2-pentanone;
With
sodium hypochlorite;
In
methanol; water;
at 3 - 10 ℃;
for 0.5h;
Industry scale;
With
hydrogenchloride;
In
methanol; water;
at 10 - 20 ℃;
Industry scale;
|
ethyl 3-hydroxy-3-methylbutanoate
3-Hydroxy-3-methylbutyric acid
Conditions | Yield |
---|---|
With
water; sodium hydroxide;
at 20 ℃;
|
93% |
With
sodium hydroxide;
In
water;
at 20 ℃;
|
93% |
The CAS number of BETA-HYDROXYISOVALERIC ACID is 625-08-1.
More information of BETA-HYDROXYISOVALERIC ACID 625-08-1 are:
CAS Number |
625-08-1 |
Density |
1.144 g/cm3 |
Melting Point |
-80 °C(lit.) |
Boiling Point |
242.8 °C at 760 mmHg |
Flash Point |
114.9 °C |
Vapor Pressure |
0.00567mmHg at 25°C |
Refractive Index |
n20/D 1.4415(lit.) |
HS CODE |
29181990 |
PSA |
57.53000 |
LogP |
0.23200 |
Pka |
4.38±0.10(Predicted) |
Synonyms for BETA-HYDROXYISOVALERIC ACID 625-08-1:b-Hydroxyisovaleric acid;b-Hydroxy-b-methylbutyric acid;3-Hydroxy-3-methylbutyric acid;3-Hydroxyisovaleric acid;3-Hydroxy-3-methylbutanoic acid;Butyricacid, 3-hydroxy-3-methyl- (6CI,7CI,8CI);
The chemical formula of BETA-HYDROXYISOVALERIC ACID is C5H10O3 which containing 5 Carbon atoms,10 Hydrogen atoms and 3 Oxygen atoms,and the molecular weight of BETA-HYDROXYISOVALERIC ACID is 118.133.
β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β- methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. It plays a part in protein synthesis and was discovered by Dr. Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs, and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as a calcium salt. Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research. The same study lists as HMB' s proposed mechanisms of action the following: Increased sarcolemmal integrity via conversion to HMG-CoA Enhanced protein synthesis via the mTOR pathway Depression of protein degradation through inhibition of the ubiquitin pathway Three grams of Calcium beta-hydroxy-beta-methylbutyrate per day may help muscles combat protein breakdown, assist in muscle repair and support increased endurance. Studies suggest its benefits may be greater for the untrained. Also, well-controlled scientific studies have found increases in muscle mass and decreases in body fat in 70 year old men. It has helped patients with chronic obstructive pulmonary disease in hospital intensive care units, muscle wasting associated with HIV or AIDS and with cancer, and trauma victims with severe injuries. The human body produces about 0.2 - 0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses.
InChI:InChI=1/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7)
Relevant articles related to BETA-HYDROXYISOVALERIC ACID:
Article |
Source |
Preparation method of calcium [beta]-hydroxy-[beta]-methylbutyrate |
- Paragraph 0025; 0027; 0030-0054, (2020/07/24) |
SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE |
- Paragraph 000642, (2019/06/05) |
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