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CasNo： 145-13-1
MF： C21H32O2
Appearance： white to off-white powder
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white to off-white powder
ChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens. Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).
The CAS number of Pregnenolone is 145-13-1.
Synonyms for Pregnenolone 145-13-1:3-beta-Hydroxypregn-5-en-20-one;3beta-Hydroxy-Delta5-pregnen-20-one;3beta-Hydroxy-5-pregnene-20-one;Delta5-Pregnen-3beta-ol-20-one;Pregn-5-ene-3beta-ol-20-one;Pregnenolone:Pregna-5-ene-3beta-ol-20-one;Arthenolone;
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
InChI:InChI=1/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18?,19?,20-,21+/m0/s1
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Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer |
Lin, Zongtao,Marepally, Srinivasa R.,Ma, Dejian,Kim, Tae-Kang,Oak, Allen Sw.,Myers, Linda K.,Tuckey, Robert C.,Slominski, Andrzej T.,Miller, Duane D.,Li, Wei , p. 5102 - 5108 (2016) |
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1,5-Hydride shift in Wolff-Kishner reduction of (20R)-3β,20, 26-trihydroxy-27-norcholest-5-en-22-one: Synthetic, quantum chemical, and NMR studies |
Szendi, Zsuzsanna,Forgo, Peter,Tasi, Gyula,Boecskei, Zsolt,Nyerges, Levente,Sweet, Frederick , p. 31 - 38 (2002) |
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Ile351, Leu355 and Ile461 residues are essential for catalytic activity of bovine cytochrome P450scc (CYP11A1) |
Glyakina, Anna V.,Strizhov, Nicolai I.,Karpov, Mikhail V.,Dovidchenko, Nikita V.,Matkarimov, Bakhyt T.,Isaeva, Ludmila V.,Efimova, Vera S.,Rubtsov, Mikhail A.,Novikova, Ludmila A.,Donova, Marina V.,Galzitskaya, Oxana V. , p. 80 - 90 (2019) |
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