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CasNo: 3054-47-5
MF: C12H19 N3 O7 S
Appearance: white crystalline powder
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S-Acetyl L-Glutathione is used for treating cataracts, glaucoma, preventing aging, treating or preventing alcoholism, asthma, cancer, heart disease (atherosclerosis and hypercholesterolemia), hepatitis, liver disease, immunosuppression (including AIDS and Chronic Fatigue Syndrome), maintaining immune function, memory loss, Alzheimer’s disease, osteoarthritis, Parkinson’s disease, people with ASD, detoxifying metals and drugs, cystic fibrosis, for preventing toxicity of chemotherapy, for treating male infertility, for preventing anaemia in patients undergoing haemodialysis, preventing renal dysfunction after coronary bypass surgery, shown to selectively induce apoptosis (cell death) in human lymphoma cancer cells.
Glutathion-S-thiolester
Conditions | Yield |
---|---|
Glutathion, Ac2O;
|
GLUTATHIONE
N5-((R)-3-(acetylthio)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine
Conditions | Yield |
---|---|
In
water; ethyl acetate; acetone; trifluoroacetic acid;
|
59% |
Multi-step reaction with 2 steps
1: dimethyl sulfoxide; aq. phosphate buffer / 0.25 h / 37 °C / pH 8.2
2: citric acid / water; dimethyl sulfoxide; aq. phosphate buffer / 4 h / pH 3
With
citric acid;
In
aq. phosphate buffer; water; dimethyl sulfoxide;
|
|
Multi-step reaction with 2 steps
1: dimethyl sulfoxide; aq. phosphate buffer / 1 h / 37 °C / pH 8.2
2: citric acid / water; dimethyl sulfoxide; aq. phosphate buffer / 4 h / pH 3
With
citric acid;
In
aq. phosphate buffer; water; dimethyl sulfoxide;
|
|
Multi-step reaction with 2 steps
1: dimethyl sulfoxide; aq. phosphate buffer / 1 h / 37 °C / pH 8.2
2: citric acid / water; dimethyl sulfoxide; aq. phosphate buffer / 4 h / pH 3
With
citric acid;
In
aq. phosphate buffer; water; dimethyl sulfoxide;
|
|
Multi-step reaction with 2 steps
1: dimethyl sulfoxide; aq. phosphate buffer / 1 h / 37 °C / pH 8.2
2: citric acid / water; dimethyl sulfoxide; aq. phosphate buffer / 4 h / pH 3
With
citric acid;
In
aq. phosphate buffer; water; dimethyl sulfoxide;
|
|
Multi-step reaction with 2 steps
1: dimethyl sulfoxide; aq. phosphate buffer / 1 h / 37 °C / pH 8.2
2: citric acid / water; dimethyl sulfoxide; aq. phosphate buffer / 4 h / pH 3
With
citric acid;
In
aq. phosphate buffer; water; dimethyl sulfoxide;
|
The CAS number of S-ACETYL-L-GLUTATHIONE is 3054-47-5.
More information of S-ACETYL-L-GLUTATHIONE 3054-47-5 are:
CAS Number |
3054-47-5 |
Density |
1.436g/cm3 |
Boiling Point |
770.2°Cat760mmHg |
Flash Point |
419.6°C |
Vapor Pressure |
5.51E-26mmHg at 25°C |
Refractive Index |
1.567 |
HS CODE |
2934999090 |
PSA |
201.19000 |
LogP |
-0.37410 |
Pka |
2.21±0.10(Predicted) |
Synonyms for S-ACETYL-L-GLUTATHIONE 3054-47-5:Glutathione,S-acetate (6CI,7CI);Glutathione, acetate (ester) (8CI);Glycine,N-(S-acetyl-N-L-g-glutamyl-L-cysteinyl)-;S-Acetylglutathione;
The chemical formula of S-ACETYL-L-GLUTATHIONE is C12H19 N3 O7 S which containing 12 Carbon atoms,19 Hydrogen atoms,3 Nitrogen atoms,7 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of S-ACETYL-L-GLUTATHIONE is 349.365.
S-acetyl-L-glutathione is a glutathione derivative that can increase intracellular glutathione similar to a prodrug. It can be used to replenish the depletion of reduced glutathione occurring during HIV infection and to inhibit HIV replication. However, it was found to selectively induce apoptosis in human lymphoma cells, Daudi, Raji and Jurkat cells, by depleting the intracellular glutathione level rather than increase it.
InChI:InChI=1/C12H19N3O7S/c1-6(16)23-5-8(11(20)14-4-10(18)19)15-9(17)3-2-7(13)12(21)22/h7-8H,2-5,13H2,1H3,(H,14,20)(H,15,17)(H,18,19)(H,21,22)
Relevant articles related to S-ACETYL-L-GLUTATHIONE:
Article |
Source |
Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis |
Adamson, Christopher,Kajino, Hidetoshi,Kanai, Motomu,Kawashima, Shigehiro A.,Yamatsugu, Kenzo supporting information, p. 14976 - 14980 (2021/09/29) |
Direct Observation of Acyl Nitroso Compounds in Aqueous Solution and the Kinetics of Their Reactions with Amines, Thiols, and Hydroxamic Acids |
Maimon, Eric,Lerner, Ana,Samuni, Amram,Goldstein, Sara , p. 7006 - 7013 (2018/09/06) |
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